JPH0518838B2 - - Google Patents

Info

Publication number
JPH0518838B2
JPH0518838B2 JP2076552A JP7655290A JPH0518838B2 JP H0518838 B2 JPH0518838 B2 JP H0518838B2 JP 2076552 A JP2076552 A JP 2076552A JP 7655290 A JP7655290 A JP 7655290A JP H0518838 B2 JPH0518838 B2 JP H0518838B2
Authority
JP
Japan
Prior art keywords
fluoro
formula
hydrogen
group
manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2076552A
Other languages
English (en)
Japanese (ja)
Other versions
JPH02275896A (ja
Inventor
Hooru Shepaado Kenesu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of JPH02275896A publication Critical patent/JPH02275896A/ja
Publication of JPH0518838B2 publication Critical patent/JPH0518838B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2076552A 1980-07-21 1990-03-26 ６―フルオロー△↑１’↑５―３―ケトステロイドおよびその製造方法 Granted JPH02275896A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/170,790 US4340538A (en) 1980-07-21 1980-07-21 Process for producing 6α-fluoro-Δ1,4 -3-keto steroids
US170790 1980-07-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP56114340A Division JPS5753500A (en) 1980-07-21 1981-07-21 Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid

Publications (2)

Publication Number Publication Date
JPH02275896A JPH02275896A (ja) 1990-11-09
JPH0518838B2 true JPH0518838B2 (en]) 1993-03-15

Family

ID=22621267

Family Applications (2)

Application Number Title Priority Date Filing Date
JP56114340A Granted JPS5753500A (en) 1980-07-21 1981-07-21 Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid
JP2076552A Granted JPH02275896A (ja) 1980-07-21 1990-03-26 ６―フルオロー△↑１’↑５―３―ケトステロイドおよびその製造方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP56114340A Granted JPS5753500A (en) 1980-07-21 1981-07-21 Manufacture of 6 alpha-fluoro-delta1,4-3- ketosteroid

Country Status (8)

Country Link
US (1) US4340538A (en])
JP (2) JPS5753500A (en])
CH (1) CH651306A5 (en])
DE (1) DE3126942A1 (en])
FR (1) FR2487360A1 (en])
GB (1) GB2080307B (en])
IT (1) IT1211076B (en])
NL (1) NL8103267A (en])

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0097328B1 (en) * 1982-06-21 1987-08-26 Dainippon Ink And Chemicals, Inc. Process for preparation of steroids
JPS63141211U (en]) * 1987-03-04 1988-09-16
IT1319654B1 (it) * 2000-11-15 2003-10-23 Farmabios S R L Ora Farmabios Processo di isomerizzazione di 6beta-fluoro steroidi neicorrispondenti 6alfa-fluoro derivati.

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1052223A (en]) *
US2841600A (en) * 1957-01-18 1958-07-01 Upjohn Co 6alpha-fluoro delta-cortisone and 6alpha-fluoro delta'-hydrocortisone and the 21-acylates thereof
US2877240A (en) * 1958-06-09 1959-03-10 Upjohn Co 6-fluoro-17beta-hydroxy-17alpha-lower aliphatic hydrocarbon-1, 4-androstadienes and 6-fluoro-17alpha-lower aliphatic hydrocarbon estradiols
US2838538A (en) * 1957-11-29 1958-06-10 Upjohn Co 6-fluoro steroids and process for preparing same
US2876219A (en) * 1958-06-09 1959-03-03 Upjohn Co 6-fluoro-9alpha-halo-11-oxygenated-4-pregnenes and 6-fluoro-9alpha-halo-11-oxygenated-1,4-pregnadienes
GB882604A (en) * 1957-11-29 1961-11-15 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US2838543A (en) * 1957-11-29 1958-06-10 Upjohn Co 6-fluoro steroids and process
US2989523A (en) * 1958-06-09 1961-06-20 Upjohn Co 2-methyl-6-fluoro compounds of the pregnane series
US2838537A (en) * 1957-11-29 1958-06-10 Upjohn Co 6-fluoro steroids and process
US2838542A (en) * 1957-11-29 1958-06-10 Upjohn Co 6-fluoro steroids and process
US2880205A (en) * 1958-06-09 1959-03-31 Upjohn Co 6-fluoro-9alpha-halo-11-oxygenated-4-pregnenes and 6-fluoro-9alpha-halo-11-oxygenated-, 4-pregnadienes
US3239540A (en) * 1958-06-09 1966-03-08 Upjohn Co 1-dehydro-6-fluoroprogesterones
US3004044A (en) * 1958-06-09 1961-10-10 Upjohn Co 1-dehydro-6-fluoro-11-oxygenated progesterones
BE642575A (en]) * 1963-01-16
US3127428A (en) * 1963-01-16 1964-03-31 Schering Corp Process for converting a 3-keto-delta-steroid to the corresponding 3-keto delta-compound
US3127430A (en) * 1963-01-16 1964-03-31 Schering Corp 17alpha-methyl-1, 5-androstadienes-17beta-ol-3-one and derivatives thereof
US3221033A (en) * 1964-07-07 1965-11-30 Schering Corp Novel process for the preparation of 1,5-bis-dehydro steroids
US4011315A (en) * 1975-07-07 1977-03-08 Syntex (U.S.A.) Inc. 21-acetals and mixed acetals of steroidal 21-aldehydes, intermediates and methods of preparation
PT69410A (fr) * 1978-04-05 1979-04-01 Syntex Inc Process pour preparation de 4-6-dihalo steroids
US4198403A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes

Also Published As

Publication number Publication date
NL8103267A (nl) 1982-02-16
CH651306A5 (de) 1985-09-13
DE3126942C2 (en]) 1992-12-03
GB2080307B (en) 1984-12-05
DE3126942A1 (de) 1982-06-03
IT1211076B (it) 1989-09-29
JPH02275896A (ja) 1990-11-09
GB2080307A (en) 1982-02-03
JPS5753500A (en) 1982-03-30
US4340538A (en) 1982-07-20
IT8122819A0 (it) 1981-07-08
JPH0250919B2 (en]) 1990-11-05
FR2487360A1 (fr) 1982-01-29
FR2487360B1 (en]) 1984-02-24

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